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Some studies use 1000 mg twice daily
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Common clinician-guided strategies include: Staying at the current dose longer before increasing, allowing the gut more time to adapt Temporarily reducing the dose , then re-advancing more slowly once symptoms improve Dividing the weekly dose into smaller, more frequent injections (when clinically appropriate and feasible) to improve tolerability Clinical context: Needing additional time or a slower titration does not mean the medication “isn’t working.” Many patients tolerate GLP-1 therapy well long-term once dosing is individualized
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